SAHA (Vorinostat)

Produktnummer ABIN1439970

Kurzübersicht für SAHA (Vorinostat) (ABIN1439970)

Applikation: Blocking Antibody (Inhibition)

Produktdetails

Produktmerkmale: HDAC inhibitor
Cutaneous T-cell lymphoma treatment
In vitro and in vivo effects on latent HIV infected T-Cells

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: RT/4 °C

Antigendetails

Hintergrund: SAHA (suberoylanilide hydroxamic acid, Vorinostat, Zolinza™) is a histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. Sirt activator based on a dihydropyridine structural scaffold. EC150 (effective concentration able to increase enzyme activity by 150%) is 1 uM for Sirt1, 25 uM for Sirt2, and 50 uM for Sirt3. The compound is active in whole cells and arrests cell cycle at G1/S phase in U937 cells. SAHA inhibits class I and class II HDACs at around 50 nM and arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 uM.

Molekulargewicht: 264.3 kDa

CAS-Nummer: 149647-78-9